ABSTRACT
Context and Objective:
Anencephaly is considered to be the most common type of neural tube defect. Our aim was to assess the clinical and gestational features of a cohort of fetuses with suspected anencephaly.
Design and Setting:
Population-based retrospective cohort study in a referral hospital in southern Brazil.
Method:
The sample consisted of fetuses referred due to suspected anencephaly, to the Fetal Medicine Service of Hospital Materno Infantil Presidente Vargas, between January 2005 and September 2013. Clinical, radiological, pathological and survival data were gathered.
Results:
Our sample was composed of 29 fetuses. The diagnosis of suspected anencephaly was made on average at 21.3 weeks of gestation. Seven fetuses had malformations that affected other organs, and
these included oral clefts (n = 4) and congenital heart defects (n = 2). In 16 cases, there was termination of pregnancy (n = 12) or intrauterine death (n = 4). Regarding those who were born alive (n = 13), all of them died in the first week of life. After postnatal evaluation, the diagnosis of anencephaly was confirmed in 22 cases (75.9%). Other conditions included amniotic band disruption complex (6.9%), microhydranencephaly (6.9%), merocrania (3.4%) and holoprosencephaly (3.4%).
Conclusions:
Different conditions involving the cranial vault may be confused with anencephaly, as seen in our sample. However, these conditions also seem to have a poor prognosis. It seems that folic acid supplementation is not being properly performed.
Source:
Emanuele Pelizzari et al, Characteristics of fetuses evaluated due to suspected anencephaly: a population-based cohort study in southern Brazil, Sao Paolo Med J. [online]. ahead of print, pp. 00-00. Epub Mar 17, 2015. ISSN 1516-3180. DOI: 10.1590/1516-3180.2013.8012608
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Anencephaly Publications
A collection of publications about anencephaly and neural tube defects for a better understanding of this birth defect.
mercredi 1 avril 2015
mercredi 13 août 2014
Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model
Abstract
Objective
To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects.
Setting
Data from two population based studies in China.
Participants
247 831 participants in a prospective community intervention project in
China (1993-95) to prevent neural tube defects with 400 μg/day folic
acid supplementation and 1194 participants in a population based
randomized trial (2003-05) to evaluate the effect of folic acid
supplementation on blood folate concentration among Chinese women of
reproductive age.
Intervention
Folic acid supplementation (400 μg/day).
Main outcome measures
Estimated RBC folate concentration at time of neural tube closure (day 28 of gestation) and risk of neural tube defects.
Results
Risk of neural tube defects was high at the lowest estimated RBC folate
concentrations (for example, 25.4 (95% uncertainty interval 20.8 to
31.2) neural tube defects per 10 000 births at 500 nmol/L) and decreased
as estimated RBC folate concentration increased. Risk of neural tube
defects was substantially attenuated at estimated RBC folate
concentrations above about 1000 nmol/L (for example, 6 neural tube
defects per 10 000 births at 1180 (1050 to 1340) nmol/L). The modeled
dose-response relation was consistent with the existing literature. In
addition, neural tube defect risk estimates developed using the proposed
model and population level RBC information were consistent with the
prevalence of neural tube defects in the US population before and after
food fortification with folic acid.
Conclusions
A threshold for “optimal” population RBC folate concentration for the
prevention of neural tube defects could be defined (for example,
approximately 1000 nmol/L). Population based RBC folate concentrations,
as a biomarker for risk of neural tube defects, can be used to
facilitate evaluation of prevention programs as well as to identify
subpopulations at elevated risk for a neural tube defect affected
pregnancy due to folate insufficiency.
Extracts:
How much natural food folate and/or folic acid intake is necessary to achieve red blood cell folate concentrations in the 1000-1300 nmol/L range in any given person or population is unknown. In the Folic Acid Dosing Trial in northern China, people consuming 100 μg/day in addition to usual diet (which is relatively low in other sources of folate) did not achieve a red blood cell folate concentration of 1000 nmol/L by the end of the six month supplementation trial. Those with the CC and CT genotypes who consumed 400 μg/day reached a red blood cell folate concentration of 1000 nmol/L between three and six months of supplementation, whereas those with the TT genotype
did not achieve a geometric mean red blood cell folate concentration of 1000 nmol/L by the six month sample.
did not achieve a geometric mean red blood cell folate concentration of 1000 nmol/L by the six month sample.
Source:
Krista S Crider, et al, Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model, BMJ 2014;349:g4554
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http://www.bmj.com/content/349/bmj.g4554
mercredi 14 mai 2014
Perinatal Hospice
Abstract:
When the prenatal diagnosis of a lethal fetal anomaly has been established, some patients choose to continue their pregnancy. Currently, there is a paucity of medical literature addressing the specific management of families in this unique circumstance. We propose a model of care that incorporates the strengths of prenatal diagnosis, perinatal grief management, and hospice care to address the needs of these families. We discuss the identification of candidates for this form of care; the multidisciplinary team approach; and the aspects of antepartum, intrapartum, and postpartum care. Finally, we discuss some barriers that might need to be overcome when attempting to implement perinatal hospice care.
Source:
Nathan J. Hoeldtke, Byron C. Calhoun, Perinatal Hospice, Am J Obstet Gynecol 2001;185:525-9
DOI: http://dx.doi.org/10.1067/mob.2001.116093
Free Fulltext:
http://www.aaplog.org/wp-content/uploads/2010/05/HoeldtkeCalhoun.pdf
When the prenatal diagnosis of a lethal fetal anomaly has been established, some patients choose to continue their pregnancy. Currently, there is a paucity of medical literature addressing the specific management of families in this unique circumstance. We propose a model of care that incorporates the strengths of prenatal diagnosis, perinatal grief management, and hospice care to address the needs of these families. We discuss the identification of candidates for this form of care; the multidisciplinary team approach; and the aspects of antepartum, intrapartum, and postpartum care. Finally, we discuss some barriers that might need to be overcome when attempting to implement perinatal hospice care.
Source:
Nathan J. Hoeldtke, Byron C. Calhoun, Perinatal Hospice, Am J Obstet Gynecol 2001;185:525-9
DOI: http://dx.doi.org/10.1067/mob.2001.116093
Free Fulltext:
http://www.aaplog.org/wp-content/uploads/2010/05/HoeldtkeCalhoun.pdf
jeudi 6 février 2014
Birth Outcomes and Maternal Residential Proximity to Natural Gas Development in Rural Colorado
Abstract
Background:
Birth defects are a leading cause of neonatal mortality. Natural gas development (NGD) emits several potential teratogens and US production is expanding.
Objectives:
We examined associations between maternal residential proximity to NGD and birth outcomes in a retrospective cohort study of 124,842 births between 1996 and 2009 in rural Colorado.
Methods:
We calculated inverse distance weighted natural gas well counts within a 10-mile radius of maternal residence to estimate maternal exposure to NGD. Logistic regression, adjusted for maternal and infant covariates, was used to estimate associations with exposure tertiles for congenital heart defects (CHDs), neural tube defects (NTDs), oral clefts, preterm birth, and term low birth weight. The Association with term birth weight was investigated using multiple linear regression.
Results:
Prevalence of CHDs increased with exposure tertile, with an odds ratio (OR) of 1.3 for the highest tertile (95% CI: 1.2, 1.5) and NTD prevalence was associated with the highest tertile of exposure (OR = 2.0, 95% CI: 1.0, 3.9, based on 59 cases), compared to no gas wells within a10-mile radius. Exposure was negatively associated with preterm birth and positively associated with fetal growth, though the magnitude of association was small. No association was foundbetween exposure and oral clefts.
Conclusions:
In this large cohort, we observed an association between density and proximity of natural gas wells within a 10-mile radius of maternal residence and prevalence of CHDs and possibly NTDs. Greater specificity in exposure estimates are needed to further explore these associations.
Journal Reference:
Lisa M. McKenzie et al, Birth Outcomes and Maternal Residential Proximity to Natural Gas Development in Rural Colorado, Environ Health Perspect; DOI:10.1289/ehp.1306722
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http://ehp.niehs.nih.gov/wp-content/uploads/122/1/ehp.1306722.pdf
mardi 28 janvier 2014
Monoamniotic Twins with One Fetal Anencephaly and Cord Entanglement Diagnosed with Three Dimensional Ultrasound at 14 Weeks of Gestation
Abstract:
A 29-year-old pregnant woman with parity 0-0-0-0 was diagnosed with monoamniotic twin pregnancy discordant for anencephaly at 14 weeks gestation. Umbilical cord entanglement, which is an important cause of fetal death in monoamniotic twins, was confirmed by three-dimensional ultrasound. Cesarean section was performed at 34 weeks of gestation, and the normal newborn infant was discharged without any complications. We report a case of monoamniotic twin pregnancy discordant for anencephaly and diagnosed with cord entanglement by three-dimensional ultrasound at 14 weeks of gestation, and now report it along with a literature review.
Journal Reference:
Jo YS, Son HJ, Jang DG, Kim N, Lee G. Monoamniotic Twins with One Fetal Anencephaly and Cord Entanglement Diagnosed with Three Dimensional Ultrasound at 14 Weeks of Gestation. Int J Med Sci 2011; 8(7):573-576. doi:10.7150/ijms.8.573.
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http://www.medsci.org/v08p0573.htm
A 29-year-old pregnant woman with parity 0-0-0-0 was diagnosed with monoamniotic twin pregnancy discordant for anencephaly at 14 weeks gestation. Umbilical cord entanglement, which is an important cause of fetal death in monoamniotic twins, was confirmed by three-dimensional ultrasound. Cesarean section was performed at 34 weeks of gestation, and the normal newborn infant was discharged without any complications. We report a case of monoamniotic twin pregnancy discordant for anencephaly and diagnosed with cord entanglement by three-dimensional ultrasound at 14 weeks of gestation, and now report it along with a literature review.
Journal Reference:
Jo YS, Son HJ, Jang DG, Kim N, Lee G. Monoamniotic Twins with One Fetal Anencephaly and Cord Entanglement Diagnosed with Three Dimensional Ultrasound at 14 Weeks of Gestation. Int J Med Sci 2011; 8(7):573-576. doi:10.7150/ijms.8.573.
Free Fulltext:
http://www.medsci.org/v08p0573.htm
jeudi 12 septembre 2013
Monoamniotic twins discordant for anencephaly managed conservatively with good outcomes: two case reports and a review of the literature
Abstract:
Monoamniotic twin pregnancy discordant for anencephaly (MATDA) is a rare occurrence with only seven prior reported cases. Selective termination has been advoated in managing discordant monoamniotic twins. We report two cases managed expectantly with good outomes and review other previously reported cases. The first case was a primigravid woman diagnosed with MATDA at 18 weeks. She was managed expectantly until 32+5 weeks when a Cesarean section was performed
for preterm labor. The surviving female infant weighed 1610 g. The second case was a multigravid woman who was diagnosed with MATDA at 17+5 weeks and was managed as an outpatient. An emergency Cesarean section was performed at 31 weeks for non-reassuring monitoring and the surviving male infant weighed 1790 g. In both cases, the survivors were discharged home in good
condition. A review of these two cases and those in the literature suggests that expectant management should be considered among management options for this rare condition.
Journal Reference:
Lim, K. I., Dy, C., Pugash, D. and Williams, K. P. (2005), Monoamniotic twins discordant for anencephaly managed conservatively with good outcomes: two case reports and a review of the literature. Ultrasound Obstet Gynecol, 26: 188–193. doi: 10.1002/uog.1947
Free Fulltext:
http://onlinelibrary.wiley.com/doi/10.1002/uog.1947/pdf
Monoamniotic twin pregnancy discordant for anencephaly (MATDA) is a rare occurrence with only seven prior reported cases. Selective termination has been advoated in managing discordant monoamniotic twins. We report two cases managed expectantly with good outomes and review other previously reported cases. The first case was a primigravid woman diagnosed with MATDA at 18 weeks. She was managed expectantly until 32+5 weeks when a Cesarean section was performed
for preterm labor. The surviving female infant weighed 1610 g. The second case was a multigravid woman who was diagnosed with MATDA at 17+5 weeks and was managed as an outpatient. An emergency Cesarean section was performed at 31 weeks for non-reassuring monitoring and the surviving male infant weighed 1790 g. In both cases, the survivors were discharged home in good
condition. A review of these two cases and those in the literature suggests that expectant management should be considered among management options for this rare condition.
Journal Reference:
Lim, K. I., Dy, C., Pugash, D. and Williams, K. P. (2005), Monoamniotic twins discordant for anencephaly managed conservatively with good outcomes: two case reports and a review of the literature. Ultrasound Obstet Gynecol, 26: 188–193. doi: 10.1002/uog.1947
Free Fulltext:
http://onlinelibrary.wiley.com/doi/10.1002/uog.1947/pdf
vendredi 30 août 2013
Fatally flawed? A review and ethical analysis of lethal congenital malformations
Abstract:
Prenatally diagnosed abnormalities that are associated with death in the newborn period are often referred to as 'lethal malformations'. Yet, for many of the commonly described lethal malformations long-term survival is possible if supportive interventions are provided. In this paper we analyse and review fetal or congenital lethal abnormalities. The designation 'lethal' overlaps with the concept of 'medical futility'. The term is used for a heterogenous group of conditions, and hinders clear communication and counselling. We argue that the term should be avoided, and propose in its place a set of key questions that should be addressed by counselling.
Extracts:
"None of the malformations that are most commonly described as being lethal are actually lethal in the strict sense. Prolonged survival has been described in all of the conditions listed, with the exeption of bilateral renal agenesis."
Journal Reference:
Wilkinson D, Thiele P, Watkins A, De Crespigny L. Fatally flawed? A review and ethical analysis of lethal congenital malformations. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03450.x.
Prenatally diagnosed abnormalities that are associated with death in the newborn period are often referred to as 'lethal malformations'. Yet, for many of the commonly described lethal malformations long-term survival is possible if supportive interventions are provided. In this paper we analyse and review fetal or congenital lethal abnormalities. The designation 'lethal' overlaps with the concept of 'medical futility'. The term is used for a heterogenous group of conditions, and hinders clear communication and counselling. We argue that the term should be avoided, and propose in its place a set of key questions that should be addressed by counselling.
Extracts:
"None of the malformations that are most commonly described as being lethal are actually lethal in the strict sense. Prolonged survival has been described in all of the conditions listed, with the exeption of bilateral renal agenesis."
"Why
is the term [lethal malformations] used? One reason is that practitioners may mistakenly
believe that conditions like those listed in Tables 1 and 2 are not
compatible with survival beyond the newborn period. A second
potential reason is a discomfort with uncertainty, or a desire to make
decision-making simpler. It is potentially easier for women to come to
terms with termination of pregnancy or with palliative care if they are
told that survival is impossible, and it may be easier for professionals
to make and rationalise such decisions. A third possibility is
that practitioners are aware that death is not inevitable but believe
that the survivors will not have a life that is worth living. Finally,
it may be that the term ‘lethal’ is believed to be an effective way of
communicating the
grave nature of the fetus’ prognosis."
grave nature of the fetus’ prognosis."
"But the problem is that 'lethal malformation' is not clear, and the way it is used hampers, rather than helps, communication. ... the term lethal is dangerous, as it contains concealed judgements about the quality of life of affected infants, and risks taking decisions out of the hand of women."
Journal Reference:
Wilkinson D, Thiele P, Watkins A, De Crespigny L. Fatally flawed? A review and ethical analysis of lethal congenital malformations. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03450.x.
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